Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury

@inproceedings{Ni2018RapidCO,
  title={Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury},
  author={Kevin Ni and Amar Nath Gill and Victor Tseng and Andrew M Mikosz and Kengo Koike and Erica L. Beatman and Cassie Y. Xu and Danting Cao and Fabienne Gally and Kara J Mould and Karina A Serban and Kelly S. Schweitzer and Keith L. March and William J Janssen and Eva Nozik-Grayck and Stavros Garantziotis and Irina Petrache},
  booktitle={Respiratory research},
  year={2018}
}
BACKGROUND Several inflammatory lung diseases display abundant presence of hyaluronic acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the extracellular matrix. The HC-HA modification is critical to neutrophil sequestration in liver sinusoids and to survival during experimental lipopolysaccharide (LPS)-induced sepsis. Therefore, the covalent HC-HA binding, which is exclusively mediated by tumor necrosis factor α (TNFα)-stimulated-gene-6 (TSG-6), may play an… CONTINUE READING
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Intravascular heavy chain-modification of hyaluronan during endotoxic shock

  • Biochemistry and biophysics reports
  • 2019
VIEW 13 EXCERPTS
CITES BACKGROUND & METHODS
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References

Publications referenced by this paper.
SHOWING 1-10 OF 70 REFERENCES

TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2016
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

25952–62

Mikecz K Ali T Mabilleau G Benayahu D Plaas A Milner CM D Mahoney DJ, osteoclast activation. J Biol Chem. 2008, 28338
  • Ni et al. Respiratory Research
  • 2018

Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury.

  • American journal of respiratory cell and molecular biology
  • 2017
VIEW 2 EXCERPTS

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