Rapid characterization of chemical constituents and rats metabolites of the traditional Chinese patent medicine Gegen-Qinlian-Wan by UHPLC/DAD/qTOF-MS.

@article{Miao2013RapidCO,
  title={Rapid characterization of chemical constituents and rats metabolites of the traditional Chinese patent medicine Gegen-Qinlian-Wan by UHPLC/DAD/qTOF-MS.},
  author={Wen-juan Miao and Qing Wang and Tao Bo and Min Ye and Xue Qiao and Wen-zhi Yang and Cheng Xiang and Xiang-yu Guan and De-an Guo},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2013},
  volume={72},
  pages={
          99-108
        }
}
Gegen-Qinlian-Wan (GQW) is a popular traditional Chinese patent medicine for the treatment of diarrhea. It is composed of four herbal medicines, Puerariae Radix, Scutellariae Radix, Coptidis Rhizoma, and Glycyrrhizae Radix. In this study, a rapid and sensitive method based on ultra high-performance liquid chromatography coupled with diode-array detection and quadrupole time-of-flight mass spectrometry (UHPLC-DAD-qTOF-MS) was established to characterize the chemical constituents and rats… Expand
Simultaneous quantification of 50 bioactive compounds of the traditional Chinese medicine formula Gegen-Qinlian decoction using ultra-high performance liquid chromatography coupled with tandem mass spectrometry.
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This study developed a solution to evaluate the quality of Gegen-Qinlian Decoction (GQD), an ancient four-herb TCM formula for the treatment of diarrhea and diabetes, together with its derived patent drugs by simultaneously quantifying 50 bioactive compounds. Expand
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Gegenqinlian decoction (GQLD) is one of the classic traditional Chinese medicines. The formula consists of four herbal medicines including Radix Puerariae lobatae, Radix Scutellariae, CoptidisExpand
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Metabolic profiling of Gegenqinlian decoction in rat plasma, urine, bile and feces after oral administration by ultra high performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry.
  • Ting Liu, X. Tian, +4 authors Zhiguo Yu
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2018
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An ultra-high performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry method was established to profile the metabolic fate of GQLD in rat plasma, urine, bile and feces and demonstrated that metabolic pathways of GqlD in rats included methylation, demethylation, hydrogenation, hydrolysis, hydroxylation, methoxylation and sulfate conjugation. Expand
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