Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood.

@article{Spahr2001RapidCI,
  title={Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood.},
  author={Laurent Spahr and Laura A Rubbia-Brandt and J{\'e}r{\^o}me Pugin and Emiliano Giostra and Jean-Louis Frossard and Bettina Borisch and Antoine Hadengue},
  journal={Journal of hepatology},
  year={2001},
  volume={35 5},
  pages={582-9}
}
BACKGROUND/AIMS In alcoholic hepatitis (AH), enhanced expression of intercellular adhesion molecule-1 (ICAM-1) correlates to neutrophil infiltration and histology. In severe AH under steroids, the evolution of the hepatocyte membranous ICAM-1 expression and its soluble form (sICAM-1) is not known. METHODS Twenty-six consecutive patients with biopsy-proven severe AH had liver tissue studies for hepatocyte membranous ICAM-1 expression by immunostaining. Lobular neutrophils (mean per high power… CONTINUE READING

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