Rapid capping in alpha-spectrin-deficient MEL cells from mice afflicted with hereditary hemolytic anemia

@article{Dahl1994RapidCI,
  title={Rapid capping in alpha-spectrin-deficient MEL cells from mice afflicted with hereditary hemolytic anemia},
  author={S C Dahl and R W Geib and Mark T. Fox and Michael A Edidin and Daniel Branton},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={125},
  pages={1057 - 1065}
}
A spectrin-based membrane skeleton is important for the stability and organization of the erythrocyte. To study the role of spectrin in cells that possess complex cytoskeletons, we have generated alpha-spectrin-deficient erythroleukemia cell lines from sph/sph mice. These cells contain beta-spectrin, but lack alpha-spectrin as determined by immunoblot and Northern blot analyses. The effects of alpha-spectrin deficiency are apparent in the cells' irregular shape and fragility in culture. Capping… CONTINUE READING

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