Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study.

@article{Chen2009RapidBO,
  title={Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study.},
  author={Chuck Chen and Zhen Liu and M{\'e}lissa Ouellet and Fr{\'e}d{\'e}ric Calon and Richard P. Bazinet},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={2009},
  volume={80 2-3},
  pages={157-63}
}
Analyses of brain phospholipid fatty acid profiles reveal a selective deficiency and enrichment in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), respectively. In order to account for this difference in brain fatty acid levels, we hypothesized that EPA is more rapidly beta-oxidized upon its entry into the brain. Wild-type C57BL/6 mice were perfused with either (14)C-EPA or (14)C-DHA via in situ cerebral perfusion for 40s, followed by a bicarbonate buffer to wash out the residual… CONTINUE READING

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