Rapid beta-lactam-induced lysis requires successful assembly of the cell division machinery.

@article{Chung2009RapidBL,
  title={Rapid beta-lactam-induced lysis requires successful assembly of the cell division machinery.},
  author={Hak Suk Chung and Zhizhong Yao and Nathan W. Goehring and Roy Kishony and Jon et Beckwith and Daniel E Kahne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 51},
  pages={21872-7}
}
Beta-lactam antibiotics inhibit penicillin binding proteins (PBPs) involved in peptidoglycan synthesis. Although inhibition of peptidoglycan biosynthesis is generally thought to induce cell lysis, the pattern and mechanism of cell lysis can vary substantially. Beta-lactams that inhibit FtsI, the only division specific PBP, block cell division and result in growth as filaments. These filaments ultimately lyse through a poorly understood mechanism. Here we find that one such beta-lactam… CONTINUE READING
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