Rapid automated determination of adenosine deaminase and lysozyme for differentiating tuberculous and nontuberculous pleural effusions.

@article{Villena1996RapidAD,
  title={Rapid automated determination of adenosine deaminase and lysozyme for differentiating tuberculous and nontuberculous pleural effusions.},
  author={Victoria Villena and J A Navarro-Gonz{\'a}lvez and C Garc{\'i}a-Benayas and J A Manzanos and Julian Echave and Angel L{\'o}pez-Encuentra and J Arenas Barbero},
  journal={Clinical chemistry},
  year={1996},
  volume={42 2},
  pages={218-21}
}
The catalytic concentration of pleural adenosine deaminase (ADA) and the ratio of pleural lysozyme (PL) to serum lysozyme (SL) were measured in consecutive patients (49 tuberculous and 179 nontuberculous) with two automated procedures in a Hitachi 717 analyzer. Using sensitivity and specificity curves, we established cutoff values at 33 U/L for ADA and 1.7 for the PL/SL ratio. The sensitivity of ADA activities for tuberculous effusion was 90%, specificity 85%. Combining ADA with the PL/SL ratio… CONTINUE READING

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