Rapid automated analysis of glutathione reductase, peroxidase, and S-transferase activity: application to cisplatin-induced toxicity.


We describe a rapid kinetic method for the automated determination of the xenobiotic-metabolizing enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase, and its application to the study of cisplatin-induced toxicity. Liver, kidney and urine from control and cisplatin-treated rats were used as the source of enzymes. Advantages… (More)


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