Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

@article{PalhanoFontes2017RapidAE,
  title={Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial},
  author={Fernanda Palhano-Fontes and Dayanna Barreto and Heloisa Helena dos Santos Onias and Katia Cristine Andrade and Morgana Menezes Novaes and J{\'e}ssica de Andrade Pessoa and S{\'e}rgio Arthuro Mota-Rolim and Fl{\'a}via de Lima Os{\'o}rio and Rafael F Sanches and Rafael Guimar{\~a}es dos Santos and Lu{\'i}s Fernando T{\'o}foli and Gabriela de Oliveira Silveira and Mauricio Yonamine and Jordi Riba and Francisco Rr Santos and Antonio A. Silva-Junior and Jo{\~a}o Carlos Alchieri and Nicole Leite Galv{\~a}o-Coelho and Bruno Lob{\~a}o-Soares and Jaime E.C. Hallak and Emerson Arcoverde and Joao Paulo Maia-de-Oliveira and Draulio Barros De Araujo},
  journal={Psychological Medicine},
  year={2017},
  volume={49},
  pages={655 - 663}
}
Abstract Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity with the Montgomery-Åsberg Depression… 

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