Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

  title={Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial},
  author={Fernanda Palhano-Fontes and Dayanna Barreto and Heloisa Helena dos Santos Onias and Katia Cristine Andrade and Morgana Menezes Novaes and J{\'e}ssica de Andrade Pessoa and S{\'e}rgio Arthuro Mota-Rolim and Fl{\'a}via de Lima Os{\'o}rio and Rafael F Sanches and Rafael Guimar{\~a}es dos Santos and Lu{\'i}s Fernando T{\'o}foli and Gabriela de Oliveira Silveira and Mauricio Yonamine and Jordi Riba and Francisco Rr Santos and Antonio A. Silva-Junior and Jo{\~a}o Carlos Alchieri and Nicole Leite Galv{\~a}o-Coelho and Bruno Lob{\~a}o-Soares and Jaime E.C. Hallak and Emerson Arcoverde and Joao Paulo Maia-de-Oliveira and Draulio Barros De Araujo},
  journal={Psychological Medicine},
  pages={655 - 663}
Abstract Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity with the Montgomery-Åsberg Depression… 

A Single Dose Of Ayahuasca Modulates Salivary Cortisol In Treatment-Resistant Depression

Findings point to new evidence of modulation of ayahuasca on salivary cortisol levels, as cortisol acts in regulation of distinct physiological pathways, emotional and cognitive processes related to etiology of depression, this modulation could be an important part of the antidepressant effects observed with ayahuaco.

A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy

Overall, analyses support the efficacy of psychedelic-assisted therapy across four mental health conditions – post-traumatic stress disorder, anxiety/depression associated with a life-threatening illness, unipolar depression, and social anxiety among autistic adults.

Acute antidepressant effect of ayahuasca in juvenile non-human primate model of depression

The results found for ayahuasca treatment corroborates in the validation of this substance as an effective antidepressant drug and encourages the return of studies with psychedelic drugs in the treatment of humor disorders, including adolescents with early-age depression.

Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls

Findings point to new evidence on the modulation of salivary cortisol levels as a result of an ayahuasca session, both in healthy and depressive volunteers.

Efficacy and Safety of Esketamine Combined with Antidepressants for Treatment-Resistant Depression: A Meta-Analysis

Meta-analysis results showed that esketamine + antidepressant has an obvious curative effect in treatment-resistant depression and can rapidly improve depression in patients, quality of life and satisfaction, but minor adverse reactions can occur.

Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up

The results suggest that ayahuasca was well tolerated and that symptom reductions were limited to a few weeks, and most patients believed that the experience was among the most important of their lives, even 4-7 years later.

Ayahuasca, a potentially rapid acting antidepressant: focus on safety and tolerability

ABSTRACT Introduction Ayahuasca is a psychedelic brew originally used by Amazonian indigenous groups and in religious rituals. Pre-clinical and observational studies have demonstrated its possible

Effects of Ayahuasca on Personality: Results of Two Randomized, Placebo-Controlled Trials in Healthy Volunteers

Ayahuasca produced inconsistent effects on personality since it induced significant increase in Openness 21 days post-drug intake only in one of the trials, which could be due to small sample sizes and baseline differences among groups.

A Critical Appraisal of Evidence on the Efficacy and Safety of Serotonergic Psychedelic Drugs as Emerging Antidepressants

The evidence supporting the efficacy and safety of serotonergic psychedelics for depression is currently of low level and future research should assess the role of expectancy and psychedelic effects in moderating and mediating treatment response.

A placebo-controlled study of the effects of ayahuasca, set and setting on mental health of participants in ayahuasca group retreats

It is suggested that improvements in mental health of participants of ayahuasca ceremonies can be driven by non-pharmacological factors that constitute a placebo response but also by pharmacological Factors that are related to the use ofAyahuasca.



Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report.

OBJECTIVES Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have

Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression: A SPECT Study

The results suggest that ayahuasca may have fast-acting and sustained antidepressive properties and should be replicated in randomized, double-blind, placebo-controlled trials.

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week.

Antidepressant effects of ketamine in depressed patients

A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder

Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.

Ketamine demonstrated rapid antidepressant effects in an optimized study design, further supporting NMDA receptor modulation as a novel mechanism for accelerated improvement in severe and chronic forms of depression.

The Therapeutic Potentials of Ayahuasca in the Treatment of Depression

This chapter reviews the major aspects of MDD such as diagnosis, current pharmacological treatments, and the motivations to use ayahuasca as a novel alternative, and speculate about the possible therapeutic potential ofAyahuasca for MDD.

Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

Psilocybin was associated with enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress, sustained benefits in existential distress and quality of life, as well as improved attitudes towards death.

Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study.