Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): A pilot study

@article{Ibrahim2011RapidAC,
  title={Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): A pilot study},
  author={Lobna Ibrahim and W Christopher Duncan and David A. Luckenbaugh and Peixiong Yuan and Carlos A. Zarate},
  journal={Brain Research Bulletin},
  year={2011},
  volume={86},
  pages={129-133}
}
While conventional antidepressants benefit many patients with major depressive disorder (MDD), as much as eight to 12 weeks can elapse before significant improvements in depressive symptoms are seen. Treatments that act more rapidly in MDD are urgently needed. Sleep deprivation (SD) has been shown to produce a rapid antidepressant response within one day in 50-60% of patients with MDD; thus, identifying its antidepressant mechanism may contribute to the development of antidepressants that act… CONTINUE READING

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