Rapid and widespread effects of 17β-estradiol on intracellular signaling in the male songbird brain: a seasonal comparison.

@article{Heimovics2012RapidAW,
  title={Rapid and widespread effects of 17β-estradiol on intracellular signaling in the male songbird brain: a seasonal comparison.},
  author={Sarah A. Heimovics and Nora H Prior and Chris J. Maddison and Kiran K. Soma},
  journal={Endocrinology},
  year={2012},
  volume={153 3},
  pages={1364-76}
}
Across vertebrate species, 17β-estradiol (E(2)) acts on the brain via both genomic and nongenomic mechanisms to influence neuronal physiology and behavior. Nongenomic E(2) signaling is typically initiated by membrane-associated estrogen receptors that modulate intracellular signaling cascades, including rapid phosphorylation of ERK. Phosphorylated ERK (pERK) can, in turn, rapidly phosphorylate tyrosine hydroxylase (TH) and cAMP response element-binding protein (CREB). Recent data suggest that… CONTINUE READING
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