Rapid and transient up-regulation of Na+/myo-inositol cotransporter transcription in the brain of acute hypernatremic rats.

@article{Minami1996RapidAT,
  title={Rapid and transient up-regulation of Na+/myo-inositol cotransporter transcription in the brain of acute hypernatremic rats.},
  author={Yasuhiro Minami and Kiyoharu Inoue and Shoichi Shimada and Hiroyuki Morimura and Akiko Miyai and Atsushi Yamauchi and Tatsuo Matsunaga and Masaya Tohyama},
  journal={Brain research. Molecular brain research},
  year={1996},
  volume={40 1},
  pages={64-70}
}
The osmoregulatory system is well developed in the brain. Osmolytes contribute to maintenance of cell volume and cellular functions without changing intracellular ionic composition. Myo-inositol is regarded as one of the major osmolytes in the brain. In the present study, we investigated the changes in expressions of sodium myo-inositol cotransporter (SMIT) mRNA in the brain of acute hypernatremic rats by in-situ hybridization and Northern blot methods. Under moderate acute hypernatremic… CONTINUE READING