Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration.

@article{Burrows2000RapidAT,
  title={Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration.},
  author={Kathleen Burrows and Gary A. Gudelsky and Bryan K. Yamamoto},
  journal={European journal of pharmacology},
  year={2000},
  volume={398 1},
  pages={11-8}
}
Metabolic mapping of discrete brain regions using cytochrome oxidase histochemistry was used as a marker for alterations in mitochondrial function and cytochrome oxidase enzymatic activity in response to high doses of amphetamine derivatives. The activity of cytochrome oxidase, complex IV of the electron transport chain, was determined at three different time-points following administration of high doses of methamphetamine or 3,4-methylenedioxymethamphetamine (MDMA) (four injections of 10-15 mg… CONTINUE READING

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