Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity.

@article{Lue2006RapidAT,
  title={Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity.},
  author={Hongqi Lue and Aphrodite Kapurniotu and Guenter Fingerle-Rowson and Thierry W. Roger and Lin Leng and Michael Thiele and Thierry Calandra and Richard Bucala and J{\"u}rgen Bernhagen},
  journal={Cellular signalling},
  year={2006},
  volume={18 5},
  pages={688-703}
}
Macrophage migration inhibitory factor (MIF) is a 12.5 kD polypeptide that serves as a critical regulator of cell functions such as gene expression, proliferation or apoptosis. However, the signal transduction pathways through which MIF takes part in cellular regulation are only incompletely understood. MIF leads to CD74-dependent "sustained" activation of ERK1/2 MAPK, but MIF's role in "transient" ERK activation and the involved upstream pathways are unknown. Here we report that the transient… CONTINUE READING

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