Rapid and specific uptake of anti-Tac disulfide-stabilized Fv by interleukin-2 receptor-bearing tumors.

@article{Webber1995RapidAS,
  title={Rapid and specific uptake of anti-Tac disulfide-stabilized Fv by interleukin-2 receptor-bearing tumors.},
  author={Kathryn Webber and Robert J. Kreitman and Ira Pastan},
  journal={Cancer research},
  year={1995},
  volume={55 2},
  pages={318-23}
}
The disulfide-stabilized Fv (dsFv) is a novel form of a variable-region fragment (Fv) of an antibody which is stabilized by an interchain disulfide bond. As a consequence, it is more stable than its Fv analogue. Anti-Tac(dsFv) is derived from anti-Tac(IgG) which specifically binds to the p55 subunit of the interleukin-2 receptor (IL2R alpha). The receptor is found in large numbers on activated T cells and many T-cell leukemias. The biodistribution patterns of 125I-anti-Tac(dsFv) and 125I-anti… CONTINUE READING

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