Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

@article{Mizutani1991RapidAS,
  title={Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase},
  author={Haruo Mizutani and Nisson Schechter and Gerald Lazarus and Roy A Black and Thomas Seth Kupper},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={174},
  pages={821 - 825}
}
  • Haruo Mizutani, Nisson Schechter, +2 authors Thomas Seth Kupper
  • Published in
    The Journal of experimental…
    1991
  • Biology, Medicine
  • Secretory granules of human dermal mast cells contain a chymotrypsin-like serine proteinase called chymase. In this study, we demonstrate that the inactive cytokine, 31 kD interleukin 1 beta (IL-1 beta), can be converted rapidly to an 18 kD biologically active species by human mast cell chymase. The product formed is three amino acids longer at the amino terminus than the mature IL-1 beta produced by peripheral blood mononuclear cells and has comparable biological activity. Because chymase is a… CONTINUE READING

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