• Corpus ID: 40464929

Rapid and simultaneous determination of tetra cyclic peptide phytotoxins, tentoxin, isotentoxin and dihydrotentoxin, from Alternaria porri by LC/MS

  title={Rapid and simultaneous determination of tetra cyclic peptide phytotoxins, tentoxin, isotentoxin and dihydrotentoxin, from Alternaria porri by LC/MS},
  author={Masayuki Horiuchi and Naoshige Akimoto and Keiichiro Ohnishi and Masakazu Yamashita and Takashi Maoka},
In the course of our investigation on bioactive products of Alternaria porri , the causal fungus of black spot disease in the stone− leek and onion, we have reported the isolation of cyclic tetra peptide, tentoxin [cyclo−(L−leucyl−N −methyl−(Z )−dehydrophenylalanyl−glycyl−N −methyl−L−alanyl), 1] [1]. Subsequently, we isolated and identified two tentoxin related cyclic peptide, isotentoxin [cyclo−(L−leucyl−N −methyl−(E )−dehydrophenylalanyl−glycyl−N Original 

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This review aims to briefly summarize the structurally different metabolites produced by Alternaria fungi, as well as their occurrences, biological activities and functions.

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Comparative chemical screening and genetic analysis reveal tentoxin as a new virulence factor in Cochliobolus miyabeanus, the causal agent of brown spot disease on rice.

Infection tests with wild-type and Cmnps3 mutants showed that tentoxin acts as a virulence factor and is correlated with chlorosis development during the second phase of infection, demonstrating that rice has previously been classified as a tentoxin-insensitive plant species, and data demonstrate that Tentoxin production by C. miyabeanus affects symptom development.

Development of a stable isotope dilution LC-MS/MS method for the Alternaria toxins tentoxin, dihydrotentoxin, and isotentoxin.

A low limit of detection was achieved with the optimization of mass spectrometry parameters and cleanup on C18-phenyl SPE columns providing a more selective binding of these phenyl-containing cyclic peptides.

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Thesis submitted in fulfillment of the requirements for the degree of doctor (PhD) in Applied Biological Sciences



Seirikassei−Tennenbutsu−kagaku (in Japa nese

  • Tokyodaigaku Syuppankai,
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The total ion chromatogram and SIM ( m/z 415 and 417) chromatograms of the ethyl acetate extract from the culture liquid of A. porri

  • 1971