Rapid and sensitive quantitation of morphine using HPLC with electrochemical detection.

@article{Mashayekhi2008RapidAS,
  title={Rapid and sensitive quantitation of morphine using HPLC with electrochemical detection.},
  author={S O Mashayekhi and Mohammadreza Ghandforoush-Sattari and Richard David William Hain},
  journal={Journal of clinical pharmacy and therapeutics},
  year={2008},
  volume={33 4},
  pages={419-27}
}
BACKGROUND Morphine is one of the most widely used opioid analgesics for controlling pain in cancer and post-operative patients. OBJECTIVE This study aimed at finding a sensitive method for measuring morphine. METHOD A one-step solid phase extraction was developed for extracting morphine from various samples, and morphine concentration was measured using a high-performance liquid chromatographic system with electrochemical detection. The sensitivity of the assay was 1.53 ng/mL with a… CONTINUE READING