Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the estimation of nicorandil in human plasma.

@article{Bhatt2006RapidAS,
  title={Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the estimation of nicorandil in human plasma.},
  author={Jignesh Bhatt and Arvind G. Jangid and Bhavin Shah and Raghavendra Shetty and Sandeep Kambli and Gunta Subbaiah and Sadhana Singh},
  journal={Biomedical chromatography : BMC},
  year={2006},
  volume={20 9},
  pages={864-9}
}
A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the estimation of nicorandil in human plasma. Nicorandil was extracted from human plasma using solid-phase extraction technique. Imipramine was used as the internal standard. A Betasil C18 column provided chromatographic separation of analytes followed by detection with mass spectrometry. The method involves a rapid solid-phase extraction from plasma, simple isocratic… CONTINUE READING

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