Rapid and sensitive high-performance liquid chromatographic method for the determination of ritonavir in human plasma.

@article{Penzak2001RapidAS,
  title={Rapid and sensitive high-performance liquid chromatographic method for the determination of ritonavir in human plasma.},
  author={Scott R. Penzak and Walter D Lawhorn and Paul O Gubbins},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2001},
  volume={39 9},
  pages={400-5}
}
Ritonavir is an HIV-1 protease inhibitor that is often used to improve the systemic availability of concurrently administered protease inhibitors by impairing their metabolism through cytochrome P450 (CYP) 3A4. Pharmacodynamic relationships between plasma ritonavir concentrations and efficacy and toxicity have also been described. To date, published high-performance liquid chromatographic (HPLC) methods for the determination of ritonavir in human plasma are often complex, requiring the use of a… CONTINUE READING