Rapid and sensitive determination of carnitine profiling by tandem mass spectrometry can be a diagnostic marker of paroxysmal atrial fibrillation

@article{Koyuncu2018RapidAS,
  title={Rapid and sensitive determination of carnitine profiling by tandem mass spectrometry can be a diagnostic marker of paroxysmal atrial fibrillation},
  author={Ismail Koyuncu},
  journal={Journal of Clinical and Analytical Medicine},
  year={2018},
  volume={9}
}
  • I. Koyuncu
  • Published 2018
  • Medicine
  • Journal of Clinical and Analytical Medicine
DOI: 10.4328/JCAM.5815 Received: 13.03.2018 Accepted: 29.03.2018 Published Online: 02.04.2018 Printed: 01.09.2018 J Clin Anal Med 2018;9(5): 447-51 Corresponding Author: İsmail Koyuncu, Harran University, Faculty of Medicine, Department of Medical Biochemistry, Şanlıurfa, Türkiye. T.: +90 414 3183209 F.: +90 4143183208 E-Mail: ismailkoyuncu1@gmail.com ORCID ID: 0000-0002-9469-4757 Abstract Aim: Paroxysmal atrial fibrillation (PAF), which is in the sub-group of atrial fibrillation that… Expand
2 Citations
Metabolomics in Lipoid Proteinosis
TLDR
It was concluded that the application of carnitine profile screening, an inexpensive, rapid, and reliable method, as a supporting laboratory test could make a contribution to the differential diagnosis for individuals with suspected LP. Expand
Qualitative and Quantitative Analysis of Resveratrol and Oxyresveratrol by Liquid Chromatography
TLDR
High performance liquid chromatography method is demonstrated as a suitable technique to understand the metabolic stability, plasma stability, pharmacokinetics and toxicokinetics of resver atrol and oxyresveratrol. Expand

References

SHOWING 1-10 OF 45 REFERENCES
Metabolic disturbances identified in plasma are associated with outcomes in patients with heart failure: diagnostic and prognostic value of metabolomics.
TLDR
A panel of metabolites, including histidine, phenylalanine, spermidine, and phosphatidylcholine C34:4, has a diagnostic value similar to B-type natriuretic peptide (BNP), and the profile of metabolites provides better prognostic value versus conventional biomarkers. Expand
The inclusion of succinylacetone as marker for tyrosinemia type I in expanded newborn screening programs.
In expanded newborn screening programs by liquid chromatography/tandem mass spectrometry false negatives for tyrosinemia type I are a significant problem. We describe a method for inclusion ofExpand
Plasma free and total carnitine measured in children by tandem mass spectrometry.
  • J. H. Osorio, M. Pourfarzam
  • Chemistry, Medicine
  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2002
TLDR
The electrospray tandem mass spectrometry method presented here is a reliable, rapid and automated procedure for carnitine quantitation, which was found to be suitable for calculating reference age-related values for free and total carnitines. Expand
Metabolomics and Incidence of Atrial Fibrillation in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study
TLDR
An association of higher levels of two bile acids with an increased risk of AF is found, pointing to a potential novel pathway in AF pathogenesis. Expand
Screening for Carnitine Palmitoyltransferase II Deficiency by Tandem Mass Spectrometry
Mitochondrial carnitine palmitoyltransferase II (CPT II) deficiency is the most common inherited disorder of lipid metabolism in adults. Currently the routine diagnosis is based on the determinationExpand
Rapid and Sensitive Differentiating Ischemic and Hemorrhagic Strokes by Dried Blood Spot Based Direct Injection Mass Spectrometry Metabolomics Analysis
TLDR
This study proved the targeted metabolomics analysis was a promising tool for rapid and timely stroke differentiation and regression model based on some of the above‐mentioned parameters, 79.07% of stroke patients from a new set could be definitely confirmed. Expand
Clinical, Biochemical, and Molecular Features in 37 Saudi Patients with Very Long Chain Acyl CoA Dehydrogenase Deficiency.
TLDR
The clinical, biochemical, molecular findings, treatment, and outcome of patients with VLCAD deficiency over the last 14 years are reported, including the most common variant and one new variant in ACADVL. Expand
[Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine].
TLDR
L-carnitine exerts a significant reduction of the VEB and its administration potentiates the anti-arrythmic effect of propafenone and mexiletine. Expand
Neonatal screening for severe combined immunodeficiency caused by an adenosine deaminase defect: a reliable and inexpensive method using tandem mass spectrometry.
TLDR
Tandem mass spectrometry can be used for diagnosis of one of the most frequent form of SCID at a negligible cost and no indeterminate or false-positive results were found. Expand
Metabolomic Profiling for the Identification of Novel Biomarkers and Mechanisms Related to Common Cardiovascular Diseases: Form and Function
TLDR
Comprehensive metabolic profiling, or “metabolomics” is increasingly being applied to CVD, leading to recent discoveries with both form and function implications, and recent progress in this rapidly expanding area is reviewed. Expand
...
1
2
3
4
5
...