Rapid and sensitive determination of acetylsalicylic acid and its metabolites using reversed-phase high-performance liquid chromatography.

@article{OKruk1984RapidAS,
  title={Rapid and sensitive determination of acetylsalicylic acid and its metabolites using reversed-phase high-performance liquid chromatography.},
  author={R. J. O'Kruk and M. Adams and R. Philp},
  journal={Journal of chromatography},
  year={1984},
  volume={310 2},
  pages={
          343-52
        }
}
A rapid and sensitive high-performance liquid chromatographic technique was developed for the simultaneous determination of gentisic acid, salicyluric acid, acetylsalicylic acid and salicylic acid in plasma and serum. The method involved a single deproteinization step and separation using a reversed-phase column eluted with a buffered methanol (35%) mobile phase. Detection was achieved with a variable-wavelength ultraviolet detector set at 235 nm and a given chromatographic analysis could be… Expand
32 Citations
Rapid high-performance liquid chromatographic assay for salicylic acid in plasma without solvent extraction.
  • 15
  • PDF
...
1
2
3
4
...

References

SHOWING 1-10 OF 20 REFERENCES
Determination of acetylsalicylic acid and salicylic acid in plasma.
  • 120
The metabolism of C14 carboxyl salicylic acid in the dog and in man.
  • 44
Determination of salicylates by GLC.
  • J. Tischio
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1976
  • 13
...
1
2
...