Rapid and sensitive detection of benzodiazepines and zopiclone in serum using high-performance thin-layer chromatography.

@article{Otsubo1995RapidAS,
  title={Rapid and sensitive detection of benzodiazepines and zopiclone in serum using high-performance thin-layer chromatography.},
  author={Kenji Otsubo and Hiroki Seto and Koujiro Futagami and Ryozo Oishi},
  journal={Journal of chromatography. B, Biomedical applications},
  year={1995},
  volume={669 2},
  pages={408-12}
}
We developed a rapid and sensitive method of identifying benzodiazepines and zopiclone in human serum using high-performance thin-layer chromatography (HPTLC). These drugs were developed and separated on plates within 8-11 min and detected by means of UV radiation and colour. Each drug was accurately identified by means of the values of RF x 100 and the spot colour in three systems. The detection limit of the benzodiazepines in serum was 0.1-0.4 micrograms/ml, except for cloxazolam and… CONTINUE READING