Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.

@article{Pabst2002RapidAS,
  title={Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.},
  author={Stefan Pabst and Martin Margittai and Darius Vainius and Ralf Langen and Reinhard Jahn and Dirk Fasshauer},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 10},
  pages={
          7838-48
        }
}
The Ca(2+)-triggered release of neurotransmitters is mediated by fusion of synaptic vesicles with the plasma membrane. The molecular machinery that translates the Ca(2+) signal into exocytosis is only beginning to emerge. The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins syntaxin, SNAP-25, and synaptobrevin are central components of the fusion apparatus. Assembly of a membrane-bridging ternary SNARE complex is thought to initiate membrane merger, but the… CONTINUE READING
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Kinetics and Thermodynamics of the Complexin SNARE Complex

E. A. Jares-Erijman, T. M. Jovin
J. Mol. Biol • 1996
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