Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction

@article{Spindler2005RapidAR,
  title={Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction},
  author={Stephen Richard Spindler},
  journal={Mechanisms of Ageing and Development},
  year={2005},
  volume={126},
  pages={960-966}
}
  • S. Spindler
  • Published 2005
  • Medicine, Biology
  • Mechanisms of Ageing and Development
It is widely held that caloric restriction (CR) extends lifespan by preventing or reducing the age-related accumulation of irreversible molecular damage. In contrast, our results suggest that CR can act rapidly to begin life and health span extension, and that its rapid genomic effects are closely linked to its health effects. We found that CR begins to extend lifespan and reduce cancer as a cause of death within 8 weeks in older mice, apparently by reducing the rate of tumor growth. Further, 8… Expand
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Caloric restriction: From soup to nuts
  • S. Spindler
  • Biology, Medicine
  • Ageing Research Reviews
  • 2010
Caloric restriction (CR), reduced protein, methionine, or tryptophan diets; and reduced insulin and/or IGFI intracellular signaling can extend mean and/or maximum lifespan and delay deleteriousExpand
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