Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction

@article{Spindler2005RapidAR,
  title={Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction},
  author={S. Spindler},
  journal={Mechanisms of Ageing and Development},
  year={2005},
  volume={126},
  pages={960-966}
}
  • S. Spindler
  • Published 2005
  • Medicine, Biology
  • Mechanisms of Ageing and Development
  • It is widely held that caloric restriction (CR) extends lifespan by preventing or reducing the age-related accumulation of irreversible molecular damage. In contrast, our results suggest that CR can act rapidly to begin life and health span extension, and that its rapid genomic effects are closely linked to its health effects. We found that CR begins to extend lifespan and reduce cancer as a cause of death within 8 weeks in older mice, apparently by reducing the rate of tumor growth. Further, 8… CONTINUE READING

    Topics from this paper.

    Identification of potential caloric restriction mimetics by microarray profiling.
    • 157
    • PDF
    Adult-onset, short-term dietary restriction reduces cell senescence in mice
    • 101
    • PDF
    Caloric restriction: From soup to nuts
    • 134
    • PDF
    Life and death: metabolic rate, membrane composition, and life span of animals.
    • 646
    • PDF
    Biological Effects of Calorie Restriction: Implications for Modification of Human Aging
    • 10

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 27 REFERENCES
    Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice
    • 398
    • PDF
    Temporal linkage between the phenotypic and genomic responses to caloric restriction.
    • 247
    • PDF
    Additive regulation of hepatic gene expression by dwarfism and caloric restriction.
    • 143
    • PDF
    Genotype and age influence the effect of caloric intake on mortality in mice
    • 184
    Molecular mechanisms linking calorie restriction and longevity.
    • 281
    Demography of Dietary Restriction and Death in Drosophila
    • 498
    • PDF