Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction

  title={Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction},
  author={S. Spindler},
  journal={Mechanisms of Ageing and Development},
  • S. Spindler
  • Published 2005
  • Medicine, Biology
  • Mechanisms of Ageing and Development
  • It is widely held that caloric restriction (CR) extends lifespan by preventing or reducing the age-related accumulation of irreversible molecular damage. In contrast, our results suggest that CR can act rapidly to begin life and health span extension, and that its rapid genomic effects are closely linked to its health effects. We found that CR begins to extend lifespan and reduce cancer as a cause of death within 8 weeks in older mice, apparently by reducing the rate of tumor growth. Further, 8… CONTINUE READING

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