Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo.

@article{Akaaboune1999RapidAR,
  title={Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo.},
  author={Mohammed Akaaboune and Susan M Culican and Stephen G Turney and Jeff William Lichtman},
  journal={Science},
  year={1999},
  volume={286 5439},
  pages={
          503-7
        }
}

• Mohammed Akaaboune, Susan M Culican, +1 author Jeff William Lichtman
• Published 1999 in Science

Quantitative fluorescence imaging was used to study the regulation of acetylcholine receptor (AChR) number and density at neuromuscular junctions in living adult mice. At fully functional synapses, AChRs have a half-life of about 14 days. However, 2 hours after neurotransmission was blocked, the half-life of the AChRs was now less than a day; the rate was 25 times faster than before. Most of the lost receptors were not quickly replaced. Direct muscle stimulation or restoration of synaptic… CONTINUE READING

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