Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo.

  title={Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo.},
  author={Mohammed Akaaboune and Susan M Culican and Stephen G Turney and Jeff William Lichtman},
  volume={286 5439},
Quantitative fluorescence imaging was used to study the regulation of acetylcholine receptor (AChR) number and density at neuromuscular junctions in living adult mice. At fully functional synapses, AChRs have a half-life of about 14 days. However, 2 hours after neurotransmission was blocked, the half-life of the AChRs was now less than a day; the rate was 25 times faster than before. Most of the lost receptors were not quickly replaced. Direct muscle stimulation or restoration of synaptic… CONTINUE READING
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