Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

@article{Brindle2002RapidAN,
  title={Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics},
  author={Joanne T. Brindle and H. Antti and E. Holmes and G. Tranter and J. Nicholson and H. Bethell and S. Clarke and P. Schofield and E. McKilligin and D. Mosedale and D. Grainger},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={1439-1445}
}
Although a wide range of risk factors for coronary heart disease have been identified from population studies, these measures, singly or in combination, are insufficiently powerful to provide a reliable, noninvasive diagnosis of the presence of coronary heart disease. Here we show that pattern-recognition techniques applied to proton nuclear magnetic resonance (1H-NMR) spectra of human serum can correctly diagnose not only the presence, but also the severity, of coronary heart disease… Expand
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