Rapid and efficient molecular analysis of gyrate atrophy using denaturing gradient gel electrophoresis.

Abstract

PURPOSE A generalized biochemical deficiency of the mitochondrial matrix enzyme ornithine aminotransferase (OAT) is the inborn error in gyrate atrophy (GA), an autosomal recessive blinding disease of the retina and choroid of the eye. Because mutations in the OAT gene show a high degree of molecular heterogeneity in GA, the authors set out to determine the… (More)

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Cite this paper

@article{Mashima1994RapidAE, title={Rapid and efficient molecular analysis of gyrate atrophy using denaturing gradient gel electrophoresis.}, author={Yukihiko Mashima and Takeru Shiono and George Inana}, journal={Investigative ophthalmology & visual science}, year={1994}, volume={35 3}, pages={1065-70} }