Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalis.

@article{Banbula1999RapidAE,
  title={Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalis.},
  author={Agnieszka Banbula and Marcin Bugno and Alice Kuster and Peter Claus Heinrich and James Travis and Jan Potempa},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={261 3},
  pages={598-602}
}
Deregulation of the cytokine network is an important adaptation of pathogenic bacteria to modulate and evade a host immune response. Here we describe that IL-6 is rapidly and efficiently cleaved and inactivated by the arginine- and lysine-specific proteinases from Porphyromonas gingivalis, referred to as RGP-A, RGP-B, and KGP. One of the primary cleavage sites for RGPs has been mapped between R18 and Q19 within the N-terminal region of the IL-6 polypeptide chain; however, both KGP and RGPs… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
24 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…