Rapid and cooperative binding of factor XII to human umbilical vein endothelial cells.

@article{Schousboe2001RapidAC,
  title={Rapid and cooperative binding of factor XII to human umbilical vein endothelial cells.},
  author={Inger Schousboe},
  journal={European journal of biochemistry},
  year={2001},
  volume={268 14},
  pages={
          3958-63
        }
}
When activated, factor XII (FXII) has been shown to play a role in a series of proteolytic cascades including systems as the fibrinolytic, the coagulation, the kallikrein-kinin and the complement. How FXII is activated in vivo remains poorly understood as the concentration and density of surface bound negative charges known to trigger the activation in vitro is far from sufficient in vivo. Specific binding of FXII to cellular receptors in the blood stream may, however, solve this problem which… CONTINUE READING