Rapid and accurate detection of SARS-CoV-2 mutations using a Cas12a-based sensing platform

@article{He2021RapidAA,
  title={Rapid and accurate detection of SARS-CoV-2 mutations using a Cas12a-based sensing platform},
  author={Changsheng He and Cailing Lin and Guosheng Mo and Binbin Xi and An′an Li and Dongchao Huang and Yan Jin Wan and Feng Chen and Yufeng Liang and Qingxia Zuo and Wanqing Xu and Dongyan Feng and Guanting Zhang and Liya Han and Changwen Ke and Hongli Du and Lizhen Huang},
  journal={Biosensors \& Bioelectronics},
  year={2021},
  volume={198},
  pages={113857 - 113857}
}
The increasing prevalence of SARS-CoV-2 variants with spike mutations has raised concerns owing to higher transmission rates, disease severity, and escape from neutralizing antibodies. Rapid and accurate detection of SARS-CoV-2 variants provides crucial information concerning the outbreaks of SARS-CoV-2 variants and possible lines of transmission. This information is vital for infection prevention and control. We used a Cas12a-based RT-PCR combined with CRISPR on-site rapid detection system… 

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