Rapid and Sensitive LC−MS–MS Method for the Determination of Sarpogrelate in Human Plasma

@article{Patankar2009RapidAS,
  title={Rapid and Sensitive LC−MS–MS Method for the Determination of Sarpogrelate in Human Plasma},
  author={Siddheshwar Patankar and Ashutosh M Pudage and Santosh Shrikrishna Joshi and Vikas V. Vaidya and Noel Alex Gomes},
  journal={Chromatographia},
  year={2009},
  volume={69},
  pages={671-676}
}
A rapid and sensitive liquid chromatographic–tandem mass spectrometric method has been developed and validated for the estimation of sarpogrelate in human plasma. Sarpogrelate was extracted from human plasma by solid-phase extraction. Temocapril was used as the internal standard. Heated electron spray ionization mass spectrometry was performed on a TSQ Quantum Ultra MS system. The LC column was a Hypurity C18 and the mobile phase was 2 mM ammonium formate (pH 3.00 ± 0.05):acetonitrile (30:70 v… CONTINUE READING

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