Rapid and Scalable Plant-based Production of a Cholera Toxin B Subunit Variant to Aid in Mass Vaccination against Cholera Outbreaks

@inproceedings{Hamorsky2013RapidAS,
  title={Rapid and Scalable Plant-based Production of a Cholera Toxin B Subunit Variant to Aid in Mass Vaccination against Cholera Outbreaks},
  author={Krystal Teasley Hamorsky and J Calvin Kouokam and Lauren J. Bennett and Keegan J. Baldauf and Hiroyuki Kajiura and Kazuhito Fujiyama and Nobuyuki Matoba},
  booktitle={PLoS neglected tropical diseases},
  year={2013}
}
INTRODUCTION Cholera toxin B subunit (CTB) is a component of an internationally licensed oral cholera vaccine. The protein induces neutralizing antibodies against the holotoxin, the virulence factor responsible for severe diarrhea. A field clinical trial has suggested that the addition of CTB to killed whole-cell bacteria provides superior short-term protection to whole-cell-only vaccines; however, challenges in CTB biomanufacturing (i.e., cost and scale) hamper its implementation to mass… CONTINUE READING