Rapid agonist-induced desensitization and internalization of the A(2B) adenosine receptor is mediated by a serine residue close to the COOH terminus.

@article{Matharu2001RapidAD,
  title={Rapid agonist-induced desensitization and internalization of the A(2B) adenosine receptor is mediated by a serine residue close to the COOH terminus.},
  author={Abneel K Matharu and Stuart James Mundell and Jeffrey L. Benovic and Elizabeth Sawyer Kelly},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 32},
  pages={
          30199-207
        }
}
The G(s)-coupled rat A(2B) adenosine receptor (A(2B)-AR) was epitope-tagged at the NH(2) terminus with hemagglutinin (HA) and subjected to progressive deletions or point mutations of the COOH terminus in order to determine regions of the receptor that contribute to agonist-induced desensitization and internalization. When expressed stably in Chinese hamster ovary cells, a mutant receptor in which the final 2 amino acids were deleted, the Leu(330)-stop mutant, underwent rapid agonist-induced… CONTINUE READING
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