Rapid activation of microglial cells by hypoxia, kainic acid, and potassium ions in slice preparations of the rat hippocampus.

@article{brahm2001RapidAO,
  title={Rapid activation of microglial cells by hypoxia, kainic acid, and potassium ions in slice preparations of the rat hippocampus.},
  author={Hajnalka {\'A}brah{\'a}m and Attila Losonczy and G L Cz{\'e}h and Gyula L{\'a}z{\'a}r},
  journal={Brain research},
  year={2001},
  volume={906 1-2},
  pages={115-26}
}
Microglial activation induced by hypoxia, kainic acid and elevated potassium concentration, all of which alter neuronal function, was studied in hippocampal slices. The activation of microglia was detected by immunostaining with a monoclonal antibody (OX-42) raised against a type 3 complement receptor (CD11b). During activation the phenotype of microglia changes and the intensity of staining of individual cells increases. Oxygen deprivation depressed the focal responses of CA1 neurons to… CONTINUE READING

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