Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase.

@article{Dmitrieva2002RapidAO,
  title={Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase.},
  author={Natalia I. Dmitrieva and Dmitry V Bulavin and Albert J. Fornace and Maurice B. Burg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 1},
  pages={184-9}
}
Cells in the kidney medulla are subject to variable and often extreme osmotic stress during concentration of the urine. Previous studies showed that renal inner medullary epithelial (IME) cells respond to hypertonicity by G(2) arrest. The purpose of the present study was to investigate the mechanisms involved in initiation and maintenance of G(2) arrest. Rapid initiation of G(2) arrest after UV radiation is mediated by p38 kinase. Here we find that p38 kinase is responsible for rapid initiation… CONTINUE READING