Rapid activation of ATM on DNA flanking double-strand breaks

@article{You2007RapidAO,
  title={Rapid activation of ATM on DNA flanking double-strand breaks},
  author={Zhongsheng You and J. Bailis and Sam A. Johnson and S. Dilworth and T. Hunter},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={1311-1318}
}
The tumour-suppressor gene ATM, mutations in which cause the human genetic disease ataxia telangiectasia (A-T), encodes a key protein kinase that controls the cellular response to DNA double-strand breaks (DSBs). DNA DSBs caused by ionizing radiation or chemicals result in rapid ATM autophosphorylation, leading to checkpoint activation and phosphorylation of substrates that regulate cell-cycle progression, DNA repair, transcription and cell death. However, the precise mechanism by which damaged… Expand
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