Rapid acquisition of 1H and 19F NMR experiments for direct and competition ligand-based screening.

Abstract

Direct and competition ligand-based NMR experiments are often used in the screening of chemical fragment libraries against a protein target due to the high relative sensitivity of NMR for protein-binding events. A plethora of NMR methods has been proposed for this purpose. Two of these techniques are the (19)F T(2) filter and the (1)H selective T(2) filter… (More)
DOI: 10.1002/mrc.2733

Cite this paper

@article{Dalvit2011RapidAO, title={Rapid acquisition of 1H and 19F NMR experiments for direct and competition ligand-based screening.}, author={Claudio Dalvit and Alvar D Gossert and J{\'e}r{\^o}me Coutant and Martial Piotto}, journal={Magnetic resonance in chemistry : MRC}, year={2011}, volume={49 4}, pages={199-202} }