Rapid acidolysis of benzyl group as a suitable approach for syntheses of peptides naturally produced by oxidative stress and containing 3-nitrotyrosine

@article{Niederhafner2015RapidAO,
  title={Rapid acidolysis of benzyl group as a suitable approach for syntheses of peptides naturally produced by oxidative stress and containing 3-nitrotyrosine},
  author={P. Niederhafner and M. {\vS}afař{\'i}k and E. Brichtov{\'a} and Jaroslav {\vS}ebest{\'i}k},
  journal={Amino Acids},
  year={2015},
  volume={48},
  pages={1087-1098}
}
Abstract 3-Nitrotyrosine (Nit) belongs to products of oxidative stress and could probably influence conformation of neurodegenerative proteins. Syntheses of peptides require availability of suitable synthon for introduction of Nit residue. Common phenolic protection groups are more acid labile, when they are attached to Nit residue. We have found that Fmoc–Nit(Bn)–OH is a good building block for syntheses of Nit containing peptides by Fmoc/tBu strategy. Interestingly, the peptides containing… Expand
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