Rapid access to unsymmetrical tolanes and alkynones by sequentially palladium-catalyzed one-pot processes.


Alkynones as well as unsymmetrically substituted tolanes (diarylalkynes) can be rapidly generated in a one-pot fashion via sequential palladium catalysis. Terminal alkynes, formed in situ by protecting-group free palladium-catalyzed coupling of aryl iodides with ethynyl magnesium bromide, are subsequently transformed by Sonogashira coupling with aryl… (More)
DOI: 10.1039/c6ob00483k