Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost

@article{Fernandez2005RapidVE,
  title={Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost},
  author={C. Fernandez and I. Stratov and R. De Rose and K. Walsh and C. J. Dale and M. Z. Smith and M. Agy and S. Hu and K. Krebs and D. Watkins and D. O’Connor and M. Davenport and S. Kent},
  journal={Journal of Virology},
  year={2005},
  volume={79},
  pages={5721 - 5731}
}
ABSTRACT Escape from specific T-cell responses contributes to the progression of human immunodeficiency virus type 1 (HIV-1) infection. T-cell escape viral variants are retained following HIV-1 transmission between major histocompatibility complex (MHC)-matched individuals. However, reversion to wild type can occur following transmission to MHC-mismatched hosts in the absence of cytotoxic T-lymphocyte (CTL) pressure, due to the reduced fitness of the escape mutant virus. We estimated both the… Expand
Quantification of simian immunodeficiency virus cytotoxic T lymphocyte escape mutant viruses.
  • L. Loh, S. Kent
  • Biology, Medicine
  • AIDS research and human retroviruses
  • 2008
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Epitope-Specific CD8+ T Cell Kinetics Rather than Viral Variability Determine the Timing of Immune Escape in Simian Immunodeficiency Virus Infection
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