Rapid Urine Drug Screens: Diphenhydramine and Methadone Cross-Reactivity

@article{Rogers2010RapidUD,
  title={Rapid Urine Drug Screens: Diphenhydramine and Methadone Cross-Reactivity},
  author={Steven C. Rogers and Charles W. Pruitt and D. Crouch and E. Caravati},
  journal={Pediatric Emergency Care},
  year={2010},
  volume={26},
  pages={665-666}
}
Background: Rapid urine screens to detect drugs of abuse are often used in pediatric emergency departments (PEDs). A positive result may lead to further clinical testing, social evaluation, and increased stress/inconvenience. A PED patient with suspected diphenhydramine (DPH) ingestion had a positive methadone result on the rapid urine drug screen, One Step Multi-Drug, Multi-Line Screen Test Device (ACON Laboratories, San Diego, Calif). There was no history of methadone exposure so the patient… Expand
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References

SHOWING 1-3 OF 3 REFERENCES
Interference of diphenhydramine with the EMIT II immunoassay for propoxyphene.
Positive diphenhydramine interference in the EMIT-st assay for tricyclic antidepressants in serum.
One Step Multi-Drug, Multi-Line Screen Test Device