Rapid UPLC-MS/MS method for routine analysis of plasma pristanic, phytanic, and very long chain fatty acid markers of peroxisomal disorders.

@article{AlDirbashi2008RapidUM,
  title={Rapid UPLC-MS/MS method for routine analysis of plasma pristanic, phytanic, and very long chain fatty acid markers of peroxisomal disorders.},
  author={Osama Y Al-Dirbashi and Tomofumi Santa and Mohamed Sanad Rashed and Zuhair N. Al-Hassnan and Nobuyuki Shimozawa and Aziza K Chedrawi and Minnie Jacob and Manhal A Al-Mokhadab},
  journal={Journal of lipid research},
  year={2008},
  volume={49 8},
  pages={1855-62}
}
Quantification of pristanic acid, phytanic acid, and very long chain fatty acids (i.e., hexacosanoic, tetracosanoic, and docosanoic acids) in plasma is the primary method for investigateing a multitude of peroxisomal disorders (PDs). Typically based on GC-MS, existing methods are time-consuming and laborious. In this paper, we present a rapid and specific liquid chromatography tandem mass spectrometric method based on derivatization with 4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-(2… CONTINUE READING
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