Rapid Trisomy Diagnosis (21, 18, and 13) Using Fluorescent PCR and Short Tandem Repeats: Applications for Prenatal Diagnosis and Preimplantation Genetic Diagnosis

@article{Findlay1998RapidTD,
  title={Rapid Trisomy Diagnosis (21, 18, and 13) Using Fluorescent PCR and Short Tandem Repeats: Applications for Prenatal Diagnosis and Preimplantation Genetic Diagnosis},
  author={Ian Findlay and Tam{\'a}s T{\'o}th and Paul Matthews and Tam{\'a}s Marton and Philip Quirke and Zolt{\'a}n Papp},
  journal={Journal of Assisted Reproduction and Genetics},
  year={1998},
  volume={15},
  pages={266-275}
}
Purpose and Methods: Prenatal diagnosis of fetal trisomies is usually performed by cytogenetic analysis from amniotic fluid. This requires lengthy laboratory procedures and high costs and is unsuitable for large-scale screening of pregnant women. An alternative method, which is rapid and inexpensive and may potentially be suitable for diagnosing trisomies even from single fetal cells, is the fluorescent polymerase chain reaction (F-PCR) using polymorphic small tandem repeats (STRs). Results: In… CONTINUE READING