Rapid Reversal of Psychotic Depression Using Mifepristone
@article{Belanoff2001RapidRO, title={Rapid Reversal of Psychotic Depression Using Mifepristone}, author={Joseph K. Belanoff and Benjamin H. Flores and Michelle Kalezhan and Brenda Sund and Alan F. Schatzberg}, journal={Journal of Clinical Psychopharmacology}, year={2001}, volume={21}, pages={516-521} }
The rationale for treating psychotic major depression with glucocorticoid receptor (GR) antagonists is reviewed. Five patients with psychotic major depression were given 600 mg of mifepristone in a 4-day, double-blind, placebo-controlled crossover study. All the patients completed the protocol and adverse effects were not observed or reported. All of the five patients showed substantial improvements in their Hamilton Rating Scale for Depression scores while they were receiving mifepristone, and…
262 Citations
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The results suggest that short-term use of mifepristone may be effective in the treatment of PMD and may re-regulate the HPA axis.
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Although the primary end point was not met, patients who attained a mifepristone plasma level of 1637 ng/mL or greater demonstrated statistically significant reductions in psychotic symptoms compared with patients who received placebo starting on day 28, and showed nonsignificant, numeric superiority on Hamilton Rating Scale for Depression improvement.
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- Psychology, MedicineJournal of clinical psychopharmacology
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