Rapid Reversal of Psychotic Depression Using Mifepristone

@article{Belanoff2001RapidRO,
  title={Rapid Reversal of Psychotic Depression Using Mifepristone},
  author={J. Belanoff and B. Flores and M. Kalezhan and B. Sund and A. Schatzberg},
  journal={Journal of Clinical Psychopharmacology},
  year={2001},
  volume={21},
  pages={516-521}
}
  • J. Belanoff, B. Flores, +2 authors A. Schatzberg
  • Published 2001
  • Medicine
  • Journal of Clinical Psychopharmacology
  • The rationale for treating psychotic major depression with glucocorticoid receptor (GR) antagonists is reviewed. Five patients with psychotic major depression were given 600 mg of mifepristone in a 4-day, double-blind, placebo-controlled crossover study. All the patients completed the protocol and adverse effects were not observed or reported. All of the five patients showed substantial improvements in their Hamilton Rating Scale for Depression scores while they were receiving mifepristone, and… CONTINUE READING
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    Topics from this paper

    Paper Mentions

    Interventional Clinical Trial
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    ConditionsPsychosis, Psychotic Depression, Severe Major Depression With Psychotic Features
    InterventionDrug
    Interventional Clinical Trial
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    ConditionsMajor Depressive Disorder, Psychotic Disorders
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