Rapid Reversal of Psychotic Depression Using Mifepristone

  title={Rapid Reversal of Psychotic Depression Using Mifepristone},
  author={J. Belanoff and B. Flores and M. Kalezhan and B. Sund and A. Schatzberg},
  journal={Journal of Clinical Psychopharmacology},
  • J. Belanoff, B. Flores, +2 authors A. Schatzberg
  • Published 2001
  • Medicine
  • Journal of Clinical Psychopharmacology
  • The rationale for treating psychotic major depression with glucocorticoid receptor (GR) antagonists is reviewed. Five patients with psychotic major depression were given 600 mg of mifepristone in a 4-day, double-blind, placebo-controlled crossover study. All the patients completed the protocol and adverse effects were not observed or reported. All of the five patients showed substantial improvements in their Hamilton Rating Scale for Depression scores while they were receiving mifepristone, and… CONTINUE READING
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