Rapid Reversal of Psychotic Depression Using Mifepristone
@article{Belanoff2001RapidRO, title={Rapid Reversal of Psychotic Depression Using Mifepristone}, author={J. Belanoff and B. Flores and M. Kalezhan and B. Sund and A. Schatzberg}, journal={Journal of Clinical Psychopharmacology}, year={2001}, volume={21}, pages={516-521} }
The rationale for treating psychotic major depression with glucocorticoid receptor (GR) antagonists is reviewed. Five patients with psychotic major depression were given 600 mg of mifepristone in a 4-day, double-blind, placebo-controlled crossover study. All the patients completed the protocol and adverse effects were not observed or reported. All of the five patients showed substantial improvements in their Hamilton Rating Scale for Depression scores while they were receiving mifepristone, and… CONTINUE READING
Topics from this paper
Paper Mentions
Interventional Clinical Trial
Approximately 450 patients will be randomized to receive mifepristone or placebo for 7 days
followed by antidepressant. The purpose is to compare the efficacy of mifepristone followed… Expand
Conditions | Psychosis, Psychotic Depression, Severe Major Depression With Psychotic Features |
---|---|
Intervention | Drug |
Interventional Clinical Trial
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called
cortisol. Under normal conditions, cortisol and other hormones are created by the body in… Expand
Conditions | Major Depressive Disorder, Psychotic Disorders |
---|---|
Intervention | Drug |
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