Rapid Retrograde Tyrosine Phosphorylation of trkA and Other Proteins in Rat Sympathetic Neurons in Compartmented Cultures

@article{Senger1997RapidRT,
  title={Rapid Retrograde Tyrosine Phosphorylation of
 trkA and Other Proteins in Rat
 Sympathetic Neurons in Compartmented Cultures},
  author={Donna L. Senger and Robert B. Campenot},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={138},
  pages={411 - 421}
}
According to the current theory of retrograde signaling, NGF binds to receptors on the axon terminals and is internalized by receptor-mediated endocytosis. Vesicles with NGF in their lumina, activating receptors in their membranes, travel to the cell bodies and initiate signaling cascades that reach the nucleus. This theory predicts that the retrograde appearance of activated signaling molecules in the cell bodies should coincide with the retrograde appearance of the NGF that initiated the… CONTINUE READING
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