Rapid Resolution of Suicidal Ideation after a Single Infusion of an NMDA Antagonist in Patients with Treatment-Resistant Major Depressive Disorder

@inproceedings{Diazgranados2010RapidRO,
  title={Rapid Resolution of Suicidal Ideation after a Single Infusion of an NMDA Antagonist in Patients with Treatment-Resistant Major Depressive Disorder},
  author={Nancy Diazgranados and Lobna A Ibrahim and Nancy E. Brutsche and Rezvan Ameli and Ioline D. Henter and David A. Luckenbaugh and Rodrigo Machado-Vieira and Carlos A. Zarate},
  year={2010}
}
Objective—Suicidal ideation is a medical emergency, especially when severe. Little research has been done on pharmacological interventions that could address this problem. Ketamine, an Nmethyl-D-aspartate (NMDA) antagonist, has been reported to have antidepressant effects within hours. We examined the effects of a single dose of ketamine on suicidal ideation in subjects with treatment-resistant major depressive disorder (MDD). Method—Thirty-three subjects with DSM-IV-diagnosed MDD received a… CONTINUE READING

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