Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling

@inproceedings{Ludzki2015RapidRO,
  title={Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling},
  author={Alison Ludzki and Sabina Paglialunga and Brennan K. Smith and Eric A. F. Herbst and Mary K. Allison and George J. F. Heigenhauser and P Darrell Neufer and Graham P Holloway},
  booktitle={Diabetes},
  year={2015}
}
Mitochondrial ADP transport may represent a convergence point unifying two prominent working models for the development of insulin resistance, as reactive lipids (specifically palmitoyl-CoA [P-CoA]) can inhibit ADP transport and subsequently increase mitochondrial reactive oxygen species emissions. In the current study, we aimed to determine if exercise training in humans diminished P-CoA attenuation of mitochondrial ADP respiratory sensitivity. Six weeks of exercise training increased whole… CONTINUE READING
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NUTRITIONAL STRATEGIES TO IMPROVE MUSCLE MITOCHONDRIAL CONTENT AND FUNCTION

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  • 2017
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