Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo

@article{Gray2006RapidRO,
  title={Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo},
  author={Noah W Gray and Robby M. Weimer and Ingrid Bureau and Karel Svoboda},
  journal={PLoS Biology},
  year={2006},
  volume={4},
  pages={180 - 189}
}
Most excitatory synapses terminate on dendritic spines. Spines vary in size, and their volumes are proportional to the area of the postsynaptic density (PSD) and synaptic strength. PSD-95 is an abundant multi-domain postsynaptic scaffolding protein that clusters glutamate receptors and organizes the associated signaling complexes. PSD-95 is thought to determine the size and strength of synapses. Although spines and their synapses can persist for months in vivo, PSD-95 and other PSD proteins… CONTINUE READING
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