Rapid Quantification and Validation of Lipid Concentrations within Liposomes

@inproceedings{Roces2016RapidQA,
  title={Rapid Quantification and Validation of Lipid Concentrations within Liposomes},
  author={Carla B. Roces and Elisabeth Kastner and Peter R Stone and Deborah S Lowry and Yvonne Perrie},
  booktitle={Pharmaceutics},
  year={2016}
}
Quantification of the lipid content in liposomal adjuvants for subunit vaccine formulation is of extreme importance, since this concentration impacts both efficacy and stability. In this paper, we outline a high performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) method that allows for the rapid and simultaneous quantification of lipid concentrations within liposomal systems prepared by three liposomal manufacturing techniques (lipid film hydration, high shear… CONTINUE READING
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